PM-94128, a new isocoumarin antitumor agent produced by a marine bacterium.

نویسندگان

  • L M Cañedo
  • J L Fernández Puentes
  • J Pérez Baz
  • C Acebal
  • F de la Calle
  • D García Grávalos
  • T García de Quesada
چکیده

with 300 ml of ^2-hexane. The water-alcohol fraction was extracted twice with 300ml of CH2C12and the active CH2C12 extracts concentrated to yield 600mg. The extract was chromatographed on a silica gel column using hexane EtOAcas eluting solvent. Fractions with antitumor activity (280 mg) were eluted with w-hexane EtOAc 75 : 25. Column chromatography on silica gel was repeated and the activity (90mg) eluted with CHC13 175

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

New anticancer antibiotics pelagiomicins, produced by a new marine bacterium Pelagiobacter variabilis.

In the course of our screening for new anticancer compounds produced by marine bacteria, we found that a new genus marine bacterium Pelagiobacter variabilis produced new phenazine antibiotics, pelagiomicins A, B and C. Those compounds were labile in water and alcohols. The absolute structure of the main component, pelagiomicin A, and the structures of the minor ones were determined from the spe...

متن کامل

Anti-MRSA activity of a bioactive compound produced by a marine Streptomyces and its optimization using statistical experimental design

Objective(s): To address the alarming problem of methicillin-resistant Staphylococcus aureus (MRSA), herein, a marine Streptomyces capable of producing an anti-MRSA compound has been studied.Materials and Methods: Strain MN41 was morphologically and physiologically characterized and then, molecularly identified using 16SrRNA analysis. To...

متن کامل

Red-pink colony-producing Pseudomonas sp. is the causative agent of mass mortality in larvae and post-larvae of Litopenaeus vannamei raised in hatcheries in south Iran

This study aimed to identify the causative of the mass mortality observed in zoeal to post-larval shrimp raised in hatcheries in south Iran. For three consecutive months, samples of nauplii and zoea of Litopenaeus vannamei were collected from an affected hatchery located in the province of Bushehr. Upon culture on marine agar, bacterial colonies that produced white, orange, yellow and red pigme...

متن کامل

A New Cyclic Hexapeptide and a New Isocoumarin Derivative from the Marine Sponge-Associated Fungus Aspergillus similanensis KUFA 0013

A new isocoumarin derivative, similanpyrone C (1), a new cyclohexapeptide, similanamide (2), and a new pyripyropene derivative, named pyripyropene T (3) were isolated from the ethyl acetate extract of the culture of the marine sponge-associated fungus Aspergillus similanensis KUFA 0013. The structures of the compounds were established based on 1D and 2D NMR spectral analysis, and in the case of...

متن کامل

Occurrence of Pseudomonas savastanoi the Causal Agent of Winter Jasmine Gall in Iran

During the years 2007 and 2008, samples of winter jasmine (Jasminum nudiflorum) with symptoms of galls on shoots were collected from Shiraz, Fars province, Iran. Gram and oxidase negative, aerobic bacterium that produced fluorescent pigment on Kingۥs B medium was isolated from galls of infected trees. All isolates produced a hypersensitive reaction in tobacco. They were negative in arginine dih...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of antibiotics

دوره 50 2  شماره 

صفحات  -

تاریخ انتشار 1997